From 1942 or so. Found on the back of a newspaper clipping.

So what exactly was in Carter’s Little Liver Pills? A laxative.

I guess not having calomel was a good thing since it often caused mercury poisoning.

The ad copy:

Wake Up Your Liver Bile — Without Calomel

— And You’ll Jump Out of Bed in the Morning Rarin’ to Go

The liver should pour out two pints of liquid bile onto the food you swallow every day. If this bile is not flowing freely, your food may not digest. You get constipated. You feel sour, sunk and the world looks punk.

It takes those good, old Carter’s Little Liver Pills to get these 2 pints of bile flowing freely to make you feel “up and up.” Get a package today. Take as directed. Effective in making bile flow freely. Ask for Carter’s Little Liver Pills. 10¢ and 25¢.